Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. II. Structural elucidation of pepticinnamin E.

Shiomi, K; Yang, H; Inokoshi, J; Van der Pyl, D; Nakagawa, A; Takeshima, H; Omura, S

Shiomi, K; Yang, H; Inokoshi, J; Van der Pyl, D; Nakagawa, A; Takeshima, H; Omura, S.

Afiliação

Shiomi K; Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.

J Antibiot (Tokyo) ; 46(2): 229-34, 1993 Feb.

Article em En | MEDLINE | ID: mdl-8468236

ABSTRACT

ABSTRACT

Structure of novel farnesyl transferase inhibitor, pepticinnamin E, is elucidated by NMR study. Pepticinnamin E is composed of five amino acids and o-pentenylcinnamic acid, having a molecular weight of 907. C-terminal glycylserine of the compounds is in the cyclized diketopiperazine form.

Assuntos

Actinomyces/metabolismo; Alquil e Aril Transferases; Oligopeptídeos/química; Transferases/antagonistas & inibidores; Sequência de Aminoácidos; Inibidores Enzimáticos/química; Dados de Sequência Molecular; Peso Molecular

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Transferases / Actinomyces / Alquil e Aril Transferases Idioma: En Ano de publicação: 1993 Tipo de documento: Article

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