Aryloxyalkyloxy- and aralkyloxy-4-hydroxy-3-nitrocoumarins which inhibit histamine release in the rat and also antagonize the effects of a slow reacting substance of anaphylaxis.
J Med Chem
; 22(2): 158-68, 1979 Feb.
Article
em En
| MEDLINE
| ID: mdl-84871
ABSTRACT
The syntheses and structure--activity relationships of a number of 4-hydroxy-3-nitrocoumarins, which are both antagonists of a slow reacting substance of anaphylaxis and potent inhibitors of antigen-induced histamine release in the rat, are described. Most active among these are 7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy(-2-hydroxypropoxy] derivatives having hydrogen or lower alkyl substituents at the C-8 position of the coumarin ring, 168, 171, 173, and 174.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
SRS-A
/
Liberação de Histamina
/
4-Hidroxicumarinas
Limite:
Animals
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article