Hypertension decreases small arteriole responses to acetylcholine in skeletal muscle.
Clin Exp Hypertens
; 15(3): 479-87, 1993 May.
Article
em En
| MEDLINE
| ID: mdl-8490593
ABSTRACT
Television microscopy was used to quantitate in vivo the responses of skeletal muscle small arterioles to acetylcholine. Five groups of rats were used normotensive and one (1K1C)- and two (2K1C)- kidney one clip renovascular hypertensive Sprague-Dawley rats (SDR), as well as WKY normotensive and spontaneously hypertensive (SHR) rats. Third-order arterioles dilated to acetylcholine with an EC50 of 3 x 10(-7) M in SDR and 10(-6) M in WKY animals. In contrast, the concentration-response curve to acetylcholine was shifted to the right (less reactive) by 100 fold in the 1K1C- and by 1000 fold in the 2K1C-hypertensives. The dose-responsive curve to acetylcholine was shifted 10-fold to the right in the SHR's compared to the WKY's. Because acetylcholine acts through endothelium-dependent mechanisms and because maximal vasodilation could be induced by an endothelium-independent vasodilator, Na-nitroprusside, in all but the 2K1C-group, we conclude that different forms of hypertension interfere to a variable degree with endothelium-dependent vasodilator mechanisms in the skeletal muscle microcirculation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arteríolas
/
Acetilcolina
/
Hipertensão Renovascular
/
Músculos
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article