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The potential value of integral membrane proteins in the vaccination of lambs against Haemonchus contortus.
Munn, E A; Smith, T S; Graham, M; Tavernor, A S; Greenwood, C A.
Afiliação
  • Munn EA; Immunology Department, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
Int J Parasitol ; 23(2): 261-9, 1993 Apr.
Article em En | MEDLINE | ID: mdl-8496009
An extract of adult Haemonchus contortus enriched in the parasite's intestinal microvillar membrane protein H11 and other integral membrane proteins but free of the protein contortin was evaluated as a potential vaccine in two breeds of sheep. The worm burdens of Clun Forest sheep injected with the extract and challenged with 25,000 infective larvae were reduced 89% by weight compared to the average for the controls. The worm burdens of Dorset sheep (challenged with 10,000 infective larvae) were reduced 72%. In both breeds the reduction in the number of female worms, 92 and 71.8%, respectively, was greater than the reduction in the males (86.5 and 46%). Parasite egg output, determined only for the Dorsets, was reduced 92% protection correlated with serum antibody titre. Most of the antibodies were directed against H11.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Ovinos / Vacinação / Hemoncose / Haemonchus / Proteínas de Membrana Limite: Animals Idioma: En Ano de publicação: 1993 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças dos Ovinos / Vacinação / Hemoncose / Haemonchus / Proteínas de Membrana Limite: Animals Idioma: En Ano de publicação: 1993 Tipo de documento: Article