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Purification and evaluation of the integral membrane protein H11 as a protective antigen against Haemonchus contortus.
Smith, T S; Munn, E A; Graham, M; Tavernor, A S; Greenwood, C A.
Afiliação
  • Smith TS; Immunology Department, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
Int J Parasitol ; 23(2): 271-80, 1993 Apr.
Article em En | MEDLINE | ID: mdl-8496010
A detergent extract of adult Haemonchus contortus enriched in the integral membrane protein H11, previously shown to give protective immunity against the parasite, was fractionated by lectin and ion-exchange chromatography. The fractions were evaluated for their ability to immunize Clun Forest and Dorset Horn sheep against experimental haemonchosis. Most of the protective activity was associated with H11. Used in an approximately 95% pure form it gave a mean reduction in parasite egg output of 94.6% and reduced male and female worm numbers by 86.5 and 93.5%, respectively. Level of protection correlated with serum antibody titre to H11.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Helminto / Haemonchus / Proteínas de Membrana / Antígenos de Helmintos Limite: Animals Idioma: En Ano de publicação: 1993 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Helminto / Haemonchus / Proteínas de Membrana / Antígenos de Helmintos Limite: Animals Idioma: En Ano de publicação: 1993 Tipo de documento: Article