Simple sequence repeat polymorphism within the p53 gene.
Oncogene
; 8(6): 1703-5, 1993 Jun.
Article
em En
| MEDLINE
| ID: mdl-8502490
ABSTRACT
This report describes a new polymorphism, in intron 3 of the p53 gene, which consists of a single repeat of 16 nucleotides, absent in the published wild-type p53 gene sequence. In the Caucasian population tested (n = 82), 28% of individuals were heterozygotes for this polymorphism. Using PCR-based analysis, we were able to demonstrate p53 allelic losses in three of six breast tumors from heterozygote patients tested.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Sequências Repetitivas de Ácido Nucleico
/
Genes p53
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article