Cloning and sequencing of a Xenopus homologue of the inducible orphan receptor NGFI-B.
Biochim Biophys Acta
; 1173(2): 239-42, 1993 May 28.
Article
em En
| MEDLINE
| ID: mdl-8504173
ABSTRACT
A cDNA clone encoding the NGFI-B transcription factor, a growth factor inducible member of the steroid/thyroid receptor superfamily, has been isolated from a Xenopus neurula (stage 17 embryo) library. Sequencing of this clone reveals an open reading frame encoding a 577 amino acid protein. Comparisons with its counterparts in rat, mouse and human show that the Xenopus protein has a well conserved DNA binding domain whereas homology in the carboxy terminal region, which includes the putative ligand binding domain, is lower than that typically observed in members of the steroid/thyroid receptor superfamily. This relative lack of homology suggests that, in Xenopus, the as-yet uncharacterized ligand may have subtle distinctions from its mammalian counterparts.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Xenopus
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article