Troponin C - troponin I interactions and molecular signalling in cardiac myofilaments.
Adv Exp Med Biol
; 382: 109-15, 1995.
Article
em En
| MEDLINE
| ID: mdl-8540387
ABSTRACT
This chapter describes a current perception of the molecular interactions regulating myofilament activity in heart cells. The focus is on the interaction between troponin-C (TnC), the Ca(2+)-receptor and troponin I (TnI), an inhibitory protein. It is this interaction that appears to form a molecular switch that turns on the thin filament. It will be seen that control of the actin-myosin reaction is not only through Ca(2+)-binding to TnC, but also through steric, cooperative and allosteric processes involving all of the main myofilament proteins-actin, myosin, tropomyosin (Tm), troponin T (TnT), TnC, and TnI. The process is modulated by covalent and non-covalent mechanisms. The process is altered in diverse myopathies and pathologies of the heart and is a target for pharmacological manipulation by a new class of inotropic agents, the "Ca(2+)-sensitizers".
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Troponina
/
Citoesqueleto de Actina
/
Cálcio
/
Miocárdio
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article