Pubarche induction with testosterone treatment in women with panhypopituitarism.
Fertil Steril
; 65(2): 437-9, 1996 Feb.
Article
em En
| MEDLINE
| ID: mdl-8566275
ABSTRACT
OBJECTIVE:
To evaluate the efficacy and safety of T therapy in the induction of pubic hair growth in women with congenital panhypopituitarism.DESIGN:
Prospective clinical study.SETTING:
Patients followed at the University Endocrinology Clinic. PATIENTS Four women with congenital panhypopituitarism, showing no pubic hair development, currently treated with substitutive therapy with L-thyroxine, cortisone acetate, and estrogen-progestin combination.INTERVENTIONS:
A long-acting T preparation (25 to 50 mg) was given IM each month; serum T levels were determined before and after 12 and 24 months of therapy. MAIN OUTCOMEMEASURE:
Evaluation of pubarche stages (according to Tanner classification of stages).RESULTS:
Patients developed pubarche (Tanner stage 3 to 5) after 3 to 18 months of T therapy. Testosterone levels were within the normal range during treatment. No hirsutism or other side effects were recorded.CONCLUSION:
A cautious T treatment represents an effective and safe approach to the problem of pubarche induction in women with congenital panhypopituitarism.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Puberdade Tardia
/
Testosterona
/
Hipopituitarismo
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article