[Detection of 3 beta-hydroxy-5-cholenoic acid in human amniotic fluid]. / Nachweis von 3beta-Hydroxy-5-cholensäure im menschlichen Fruchtwasser
Schweiz Med Wochenschr
; 107(15): 529-31, 1977 Apr 16.
Article
em De
| MEDLINE
| ID: mdl-857310
ABSTRACT
Studies of the bile acids of human meconium suggest that a fetal pathway of bile acid synthesis exists which leads to formation of 3beta-hydroxy-5-cholenoic acid, a bile acid not found in serum of healthy pregnant women. To obtain additional support for this hypothesis, cholic, chenodeoxycholic, and 3beta-hydroxy-5-cholenoic acid were measured in amniotic fluid specimens from 18 pregnant women without liver disease. The finding of a considerable percentage of 3beta-hydroxy-5-cholenoic acid (mean 34 molar %; range 3-71 molar % of total bile acids) in amniotic fluid strengthens the hypothesis that a fetal pathway of bile acid synthesis exists which begins with oxidation of the cholesterol side chain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos e Sais Biliares
/
Líquido Amniótico
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
De
Ano de publicação:
1977
Tipo de documento:
Article