Aminoglycoside pharmacokinetics and -dynamics: a nonlinear approach.

ABSTRACT

A model which correctly describes the pharmacokinetic-pharmacodynamic relationship is necessary to perform a rational pharmacotherapy. This model could predict the effects under variable conditions. The prediction will provide a basis for adapting therapy to individuals. A nonlinear model should be most appropriate for describing drug effects. A new model, containing nonlinear pharmacokinetics and pharmacodynamics, is presented to describe effects of aminoglycosides on bacterial growth and accumulation in kidney tissue.