CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the map kinases: ERK2 and Jun kinases.
Mol Immunol
; 33(1): 63-70, 1996 Jan.
Article
em En
| MEDLINE
| ID: mdl-8604225
ABSTRACT
The present study compares the mitogen-activated protein (MAP) kinase responses in T cells activated with the CD28 ligands B7-1 (CD80) and B7-2/B70 (CD86). Ligands B7-1 and B7-2 do not activate the Raf-1/ERK2 cascade, but share the ability to activate related Jun kinases. These natural ligands for CD28 had no stimulatory effect alone on Jun kinase activation, but the data show that B7-1 and B7-2 could both co-operate with intracellular Ca2+ increase and protein kinase C (PKC) activation to stimulate Jun kinases. The present study shows that the interaction of CD28 with its ligands B7-1 and B7-2 can induce identical signal transduction through the MAP kinase cascades.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Antígenos CD
/
Proteínas Quinases Dependentes de Cálcio-Calmodulina
/
Antígeno B7-1
/
Antígenos CD28
/
Proteínas Quinases Ativadas por Mitógeno
Limite:
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article