In vitro interactions between different beta-lactam antibiotics and fosfomycin against bloodstream isolates of enterococci.
Antimicrob Agents Chemother
; 39(10): 2341-4, 1995 Oct.
Article
em En
| MEDLINE
| ID: mdl-8619593
ABSTRACT
The effects of 16 different beta-lactam-fosfomycin combinations against 50 bloodstream enterococci were compared by a disk diffusion technique. Cefotaxime exhibited the best interaction. By checkerboard studies, the cefotaxime-fosfomycin combination provided a synergistic bacteriostatic effect against 45 of the 50 isolates (MIC of cefotaxime at which 90% of the isolates were inhibited, >2,048 micrograms/ml; MIC of fosfomycin at which 90% of the isolates were inhibited, 128 micrograms/ml; mean of fractional inhibitory concentration indexes, 0.195). By killing curves, cefotaxime (at 64 micrograms/ml) combined with fosfomycin (at > or = 64 micrograms/ml) was bactericidal against 6 of 10 strains tested.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Enterococcus
/
Bacteriemia
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Quimioterapia Combinada
/
Fosfomicina
/
Antibacterianos
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article