Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers.
Science
; 271(5253): 1289-91, 1996 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-8638112
ABSTRACT
In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Linfotoxina-alfa
/
Receptores do Fator de Necrose Tumoral
/
Centro Germinativo
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article