Complementation cloning of mammalian transcriptional regulators: the example of MHC class II gene regulators.
Curr Opin Genet Dev
; 5(5): 646-51, 1995 Oct.
Article
em En
| MEDLINE
| ID: mdl-8664553
ABSTRACT
Cloning by complementation of mutant cell lines is a powerful way in which to identify and isolate important regulatory genes on the basis of functional assays. The recent cloning of two essential regulators of major histocompatibility complex (MHC) class II gene expression has not only advanced our understanding of the complex mechanisms controlling these genes, but also helps to illustrate the feasibility of this approach for the study of mammalian gene regulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Transativadores
/
Regulação da Expressão Gênica
/
Genes MHC da Classe II
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article