A multiple-pathway model for the diffusion of drugs in skin.
IMA J Math Appl Med Biol
; 13(2): 127-50, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8671583
ABSTRACT
A mathematical model for the diffusion of drugs in skin is presented. The penetration of the drug by both transcellular and intercellular pathways, as well as its interchange between these pathways, is considered. A pharmacologically motivated asymptotic limit is identified and analysed to obtain, in particular, an analytical expression for the flux of drug to the blood at steady state. Relevant model data is discussed, and some numerical results are also presented.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Absorção Cutânea
/
Preparações Farmacêuticas
/
Matemática
/
Modelos Biológicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article