The role of pterins in depression and the effects of antidepressive therapy.
Biol Psychiatry
; 38(7): 458-63, 1995 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-8672606
ABSTRACT
Urinary excretion of neopterins (N) and biopterins (B) was measured in 48 patients with depression before and after treatment with placebo, antidepressants, or electroconvulsive therapy (ECT), and in 26 healthy control subjects. Patients prior to and after treatment had a significantly greater neopterin/biopterin (NB) ratio than control subjects. There was a significant correlation between NB ratios and the severity of depression and plasma cortisol. As a raised NB ratio implies failure to convert neopterin to biopterin, it is possible that reduced availability of tetrahydrobiopterin, the essential cofactor for the formation of noradrenaline, serotonin and dopamine, may exert rate-limiting control over the synthesis of monoamines implicated in the pathogenesis of depressive illness.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biopterinas
/
Transtorno Depressivo
/
Eletroconvulsoterapia
/
Antidepressivos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article