Imaging and biodistribution of 125I tyramine oligonucleotide in nude mice bearing human breast tumor. Preliminary report.
Bull Cancer
; 83(1): 23-26, 1996 Jan.
Article
em En
| MEDLINE
| ID: mdl-8672852
Although the range of applications for antisense oligonucleotides is vast, current research concentrates mainly on virology and oncology. We have conducted in vivo and in vitro investigations of radiolabelling and biodistribution of a 22-mer phosphodiester oligonucleotide injected in athymic mice bearing xenograft of human mammary tumor (coculture: MCF7 and fibroblasts strain AF-11). Tumor/healthy tissue ratio of the 22-mer phosphodiester oligonucleotide fixation is high during the 24 hours after injection instead of fast elimination.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiramina
/
Oligonucleotídeos Antissenso
/
Modelos Animais de Doenças
/
Radioisótopos do Iodo
/
Neoplasias Mamárias Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article