Effects of a single heparin bolus on neointimal growth after arterial injury in intact rabbits.
Angiology
; 47(6): 549-56, 1996 Jun.
Article
em En
| MEDLINE
| ID: mdl-8678329
ABSTRACT
Heparinization is a routine procedure during angioplasty; however, its consequences on the late vascular response to a severe injury are unclear. The authors' objective was to explore the effect of a single heparin bolus at the time of a severe vascular injury on late intimal proliferation and neointimal thickening. The iliac artery of 57 normolipemic rabbits was overdistended with a balloon catheter. Heparin (250 IU/kg i.v.) was given to 29 rabbits ten minutes before angioplasty, whereas 28 rabbits served as untreated controls. Neointimal thickening was prominent at fourteen days after injury and reached near-maximal values at day 28. The intimal/medial area ratio was reduced by an average 28.3% with heparin (at day 28 2.19 +/- 0.51 vs 1.57 +/- 0.59, control vs heparin, P = 0.02). Neointimal cells stained positively for HHF-35 antibody, directed against smooth muscle cell antigens. Neointimal proliferation, quantified through the number of cell nuclei peroxidase-stained for PCNA/cyclin antigen, was significantly decreased by 43% and 49% with heparin, respectively, at days 7 and 14 after injury. These data suggest that early exposure even to low doses of heparin accounts for much of its inhibitory effect in vascular response to injury; such an effect might prove important in interpreting results of human trials of interventions against restenosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cateterismo
/
Heparina
/
Túnica Íntima
/
Artéria Ilíaca
/
Anticoagulantes
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article