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Synthesis and cytotoxic activity of peptides containing basic amino acids residues.
Chillemi, F; Francescato, P; Bossa, R; Fraccari, A; Galatulas, I.
Afiliação
  • Chillemi F; Dipartamento di Chimica Organica e Industriale dell'Universitá di Milano, Italy.
Anticancer Res ; 16(2): 715-6, 1996.
Article em En | MEDLINE | ID: mdl-8687118
We synthesized eight peptides containing from three to twenty residues of arginine, lysine and histidine, using an automated synthetiser and Fmoc strategy. All peptides were purified by preparative reverse-phase HPLC and characterized by electrospay mass spectometry. Cytotoxic activity was assessed on HeLa cells. One peptide inhibited the colony-forming ability of tumor cells.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos Limite: Humans Idioma: En Ano de publicação: 1996 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos Limite: Humans Idioma: En Ano de publicação: 1996 Tipo de documento: Article