Extra Y chromosome in T-cell acute lymphoblastic leukemia.
Cancer Genet Cytogenet
; 89(1): 85-7, 1996 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-8689620
ABSTRACT
We describe a 66-year-old man who developed T-cell acute lymphoblastic leukemia (ALL) with a sole clonal chromosomal abnormality of 47,XY,+Y. Leukemic cells were positive for CD2, CD7, terminal deoxynucleotidyl transferase and cytoplasmic CD3. T-cell receptor beta, gamma, and delta genes remained germline configurations. The bone marrow aspirate was 47,XY,+Y in all metaphase cells observed. The patient achieved complete remission by chemotherapy, and the bone marrow cells and the phytohemagglutinin stimulated peripheral blood lymphocytes showed a normal karyotype of 46,XY at that time. This fact suggests that an extra Y chromosome may be a kind of new chromosomal abnormality of T-cell ALL.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomo Y
/
Leucemia-Linfoma de Células T do Adulto
/
Aberrações Cromossômicas
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article