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CG5/Dx human breast cancer cell line: characterization of a new doxorubicin-resistant variant.
Gibelli, N; Zibera, C; Asti, A; Maestri, L; Bacchella, L; Pedrazzoli, P; Calligaro, A; Robustelli della Cuna, G.
Afiliação
  • Gibelli N; Divisione di Oncologia Medica, Università degli Studi, Pavia, Italy.
Anticancer Res ; 16(4A): 1675-81, 1996.
Article em En | MEDLINE | ID: mdl-8712686
By continuous exposure of CG5 human breast cancer cell line to increasing doxorubicin (Dx) concentrations, a multidrug-resistant (MDR) subline (CG5/Dx) was obtained. The resistant variant showed P-glycoprotein (P-gp) expression and a lower intracellular doxorubicin level than the parental cells. CG5/Dx cells were 19.4 fold more resistant to Dx than CG5 cells and showed a cross-resistance to some structurally related and unrelated compounds. Differences in kinetics, biological and ultrastructural features between the two cell lines were investigated. The CG5/Dx cells grew more slowly, produced higher CEA levels and showed a reduced progesterone receptor (PgR) content than the parental cells. Ultrastructural studies revealed differences involving, polyribosomes, rough endoplasmic reticulum, [mitochondria] and cytoskeleton.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doxorrubicina / Membro 1 da Subfamília B de Cassetes de Ligação de ATP / Resistência a Múltiplos Medicamentos / Resistencia a Medicamentos Antineoplásicos / Antibióticos Antineoplásicos Limite: Female / Humans Idioma: En Ano de publicação: 1996 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doxorrubicina / Membro 1 da Subfamília B de Cassetes de Ligação de ATP / Resistência a Múltiplos Medicamentos / Resistencia a Medicamentos Antineoplásicos / Antibióticos Antineoplásicos Limite: Female / Humans Idioma: En Ano de publicação: 1996 Tipo de documento: Article