Human glomerular basement membrane. Heterogeneity of antigenic determinants.
Biochim Biophys Acta
; 553(2): 244-54, 1979 May 17.
Article
em En
| MEDLINE
| ID: mdl-87223
ABSTRACT
Human glomerular basement membrane was solubilized by digestion with proteolytic enzymes and immunoreactive components were quantitated and characterized by using rabbit antibodies raised against the particulate membrane. A number of antigens were demonstrated but they did not separate on gel filtration. However, two antigenic components in a collagenase digest of the membrane could be separated and isolated by Sepharose 6B chromatography. Chemical characterization suggests that both fragments are noncollagenous glycopeptides (molecular weights approx. 1,000,000 and 60,000--200,000, respectively).
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Basal
/
Glomérulos Renais
Limite:
Humans
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article