Biphasic transforming growth factor-beta production flanking the pro-inflammatory cytokine response in cerebral trauma.
Neuroreport
; 7(1): 133-6, 1995 Dec 29.
Article
em En
| MEDLINE
| ID: mdl-8742435
ABSTRACT
We determined the time-course of the production of transforming growth factor-beta (TGF-beta) after fluid-percussion injury using a bioassay. Biophasic production of TGF-beta composed mainly of TGF-beta 2 was detected in the ipsilateral cortex, with a first peak 30 min and a second peak 48 h after the lesion, flanking the transient production of tumor necrosis factor-alpha and interleukin-6 occurring between 5 and 18 h after trauma. This temporal pattern suggested that TGF-beta plays alternatively a pro- and anti-inflammatory role in the regulation of the brain cytokine network in response to injury, providing an endogenous mechanism for the control of the inflammatory reaction in traumatic brain injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Encefálicas
/
Córtex Cerebral
/
Fator de Crescimento Transformador beta
/
Interleucina-6
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Fator de Necrose Tumoral alfa
/
Inflamação
Limite:
Animals
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article