[Amphotericin B into parenteral lipid emulsions. Galenic stability of mixtures. Preliminary results]. / L'amphotéricine B dans des émulsions lipidiques parentérales. Stabilité galénique des mélanges. Résultats préliminaires.
Pathol Biol (Paris)
; 44(5): 384-8, 1996 May.
Article
em Fr
| MEDLINE
| ID: mdl-8758481
ABSTRACT
The amphotericin B in glucose solution is the reference's treatment of the major systemic mycoses. Because of its bad tolerance, certain authors put forward others vehicules such as fat emulsions. The aim of our work has been to study the physico-chemical stability of two regeneration's methods; P1 direct regeneration. P2 regeneration of 50mg of Fungizone in 5 ml of glucose serum and laced with 45 ml of Ivelip 20% versus PR 50 mg of Fungizone in 50 ml of glucose serum. Our results seem to show that the P1 is totally incompatible with a parenteral administration, because 23% of the granulometric population has a diameter superior to 5 microns. The solution P2 seems better even if the pH is different from PR and a light depot comes after reconstitution.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anfotericina B
/
Emulsões Gordurosas Intravenosas
/
Antifúngicos
Idioma:
Fr
Ano de publicação:
1996
Tipo de documento:
Article