Biological monitoring of occupational exposure to contraceptive drugs.

ABSTRACT

The present study was carried out for screening some biochemical changes due to occupational exposure to contraceptive drugs. It included 18 male workers and 22 female workers involved in the manufacture of contraceptive pills and 34 female workers manufacturing contraceptive ampoules. The levels of some sex hormones and gonadotropins were evaluated. Some parameters of blood picture, blood coagulation, liver and kidney functions, lipid profile and trace elements metabolism were assessed. Results were compared with those of a control group composed of 19 males and 27 females. Increased levels of estrogen among exposed workers was the main finding. It has been attributed to liver rather than pituitary dysfunction. A less atherogenic lipid profile has also been found. Referral to preventive measures has been recommended.