Guidelines for efficient peripheral blood progenitor cell collection.
Neth J Med
; 48(1): 29-37, 1996 Jan.
Article
em En
| MEDLINE
| ID: mdl-8775750
ABSTRACT
In recent years peripheral blood progenitor cells (PBPC) have increasingly been used to support hematological recovery after high-dose chemotherapy treatment. PBPC are collected by leukopheresis after mobilization by chemotherapy and/or hematopoietic growth factors. Efficient mobilization and correct timing of leukopheresis is essential to minimize the number of leukophereses required for collection of sufficient PBPC for transplantation. Mobilization efficiency is influenced by various factors and recruitment of cells can be assessed by cell assays and FACS analysis. Target values of cells required for rapid hematological reconstitution after high-dose chemotherapy have been reported, but threshold values for various conditions still need to be established. CD34+ selection of the leukopheresis is of value for tumor cell purging and may be important for reduction of relapse rate of solid tumors and hematological malignancies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Leucaférese
/
Transplante de Células-Tronco Hematopoéticas
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article