Characterisation of human cyclin G1 and G2: DNA damage inducible genes.
Oncogene
; 13(5): 1103-9, 1996 Sep 05.
Article
em En
| MEDLINE
| ID: mdl-8806701
ABSTRACT
Several genes have been identified as targets for transcriptional activation by the p53 tumour suppressor protein. Rodent cyclin G was previously identified as a p53 responsive gene and in order to assess the role played by cyclin G as a mediator of p53 function in humans cells we have isolated full length human cyclin G1 and identified a related gene designated cyclin G2. Both human G-cyclins are induced by the DNA damaging agent actinomycin-D and although the induction of cyclin G1 is clearly p53 dependent, activation of cyclin G2 expression was observed in the absence of p53. Based on sequence similarity, the G-cyclins and the recently identified cyclin I form a distinct sub-group within the larger cyclin family, possibly reflecting some degree of functional similarity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Ciclinas
Limite:
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article