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Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.
Duffy, P M; Hayes, M C; Cooper, A; Smart, C J.
Afiliação
  • Duffy PM; Department of Urology, Southampton University Hospitals NHS Trust, U.K.
Br J Cancer ; 74(6): 906-9, 1996 Sep.
Article em En | MEDLINE | ID: mdl-8826856
Idarubicin is a highly lipophilic anthracycline and appears effective against tumours resistant to conventional anthracyclines. Confocal microscopy demonstrates predominantly cytoplasmic idarubicin accumulation. This distribution is unaltered by resistance status or the resistance reversing agent verapamil. Our results contrast with studies on conventional anthracyclines and suggest that nuclear accumulation may not be a prerequisite for anthracycline cytotoxicity.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Idarubicina / Antibióticos Antineoplásicos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 1996 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Idarubicina / Antibióticos Antineoplásicos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 1996 Tipo de documento: Article