Protection from natural killer cell-mediated lysis by HLA-G expression on target cells.
Science
; 274(5288): 792-5, 1996 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-8864122
ABSTRACT
The outermost layer of the human placenta is devoid of classical class I human leukocyte antigens (HLA-A, HLA-B, and HLA-C) and class II proteins (HLA-DR, HLA-DQ, and HLA-DP). Although this prevents recognition by maternal T lymphocytes, the lack of class I molecules leaves these cells susceptible to attack by natural killer (NK) cells. However, trophoblast cells directly in contact with the maternal tissues express the class I molecule HLA-G, which may be involved in protecting the trophoblast from recognition by NK cells. Here evidence is provided that expression of HLA-G is sufficient to protect otherwise susceptible target cells from lysis by activated NK1 and NK2 cell lines and clones that are specific for distinct groups of HLA-C alleles. The receptors on NK cells that recognize HLA-G are also identified.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Antígenos de Histocompatibilidade Classe I
/
Citotoxicidade Imunológica
/
Antígenos HLA
Limite:
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article