Borrelia burgdorferi possesses a collagenolytic activity.
FEMS Microbiol Lett
; 144(1): 39-45, 1996 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-8870250
ABSTRACT
Lyme disease is a multisystemic disorder caused by Borrelia burgdorferi, an invasive spirochete. B. burgdorferi has a predilection for collagenous tissue and one major clinical manifestation of the disease is arthritis. We have identified a collagenolytic activity in B. burgdorferi detergent lysates using iodinated gelatin as well as iodinated pepsinized human collagen types II and IV as protein substrates. In addition, we describe several proteolytic activities in B. burgdorferi with molecular masses greater than 200 kDa on sodium dodecyl sulfate polyacrylamide gels containing copolymerized gelatin. We propose that the collagenolytic activity of B. burgdorferi has a role in invasion, in the pathogenesis of Lyme arthritis, and perhaps also in other manifestations of Lyme borreliosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Grupo Borrelia Burgdorferi
/
Colágeno
/
Gelatina
Limite:
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article