Your browser doesn't support javascript.
loading
Prolongation of rat liver graft survival by splenectomy combined with low dose FK506 therapy.
Kashu, Y; Abe, Y; Miyauchi, K; Watanabe, Y; Sato, M; Sato, N; Kimura, S.
Afiliação
  • Kashu Y; Department of Surgery II, Ehime University, School of Medicine, Japan.
Artif Organs ; 20(10): 1116-9, 1996 Oct.
Article em En | MEDLINE | ID: mdl-8896731
ABSTRACT
The effects of low dose FK506 therapy (0.1 mg/ kg/day x 1 day) on graft survivals were analyzed, and the feasibility of splenectomy was assessed. ACI strain liver grafts were orthotopically implanted into LEW male rat recipients. In the control group, the survival period was 10.4 +/- 1.4 days. In the group treated with splenectomy, the survival period was 13.4 +/- 2.0 days. In the groups with low dose FK506 therapy, the survival periods were 22.7 +/- 6.7 and 39.7 +/- 6.3 days with or without splenectomy, respectively. Rats in the group with average dose FK506 (1.0 mg/kg/day x 7 days) survived more than 100 days. In summary, the effect of low dose FK506 therapy was relatively limited. Splenectomy by itself was marginally effective; however, this effect was enhanced when combined with low dose FK506 therapy.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Tacrolimo / Sobrevivência de Enxerto / Imunossupressores Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 1996 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Tacrolimo / Sobrevivência de Enxerto / Imunossupressores Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 1996 Tipo de documento: Article