A QSAR study of anti-inflammatory N-arylanthranilic acids.
J Pharm Pharmacol
; 48(9): 883-6, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8910845
ABSTRACT
A detailed quantitative structure-activity relationship (QSAR) analysis of a series of 112 anti-inflammatory N-arylanthranilic acids has been performed to determine which physicochemical properties of these compounds are responsible for their anti-inflammatory activity. The results indicate that activity is modelled best by molecular shape parameters. The angle between the planes of the two benzene rings, dictated by the substitution pattern of the compounds, also appears relevant to activity. Dipole moments show some significance, but log P and other physiochemical parameters correlate poorly with activity. The best QSAR obtained was [equation see text] where B1 and B3 are Verloop substituent width parameters and mu(bond) is bond dipole (position in parentheses).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
/
Ortoaminobenzoatos
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article