Combination therapy with granulocyte colony-stimulating factor, all-trans retinoic acid, and low-dose cytotoxic drugs for acute myelogenous leukemia.
Intern Med
; 34(12): 1186-9, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-8929647
A 67-year-old man presented with acute myelogenous leukemia (M2). Peripheral blood examination revealed a leukocyte count of 1,700/mu l with 1% myeloblasts, and bone marrow aspiration showed 42.6% myeloblasts with Auer bodies. Culture of his marrow cells at diagnosis showed that granulocyte colony-stimulating factor (G-CSF) promoted cell proliferation, while all-trans retinoic acid (ATRA) inhibited the proliferative effect of G-CSF and induced differentiation. Combination therapy with G-CSF, ATRA, and low-dose cytotoxic drugs achieved complete remission without severe marrow suppression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arabinonucleotídeos
/
Tretinoína
/
Leucemia Mieloide Aguda
/
Fator Estimulador de Colônias de Granulócitos
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Ciclofosfamida
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Monofosfato de Citidina
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Imunossupressores
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Antineoplásicos
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article