N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss.
Nat Med
; 2(12): 1338-43, 1996 Dec.
Article
em En
| MEDLINE
| ID: mdl-8946832
ABSTRACT
The use of aminoglycoside antibiotics is limited by ototoxicity that can produce permanent hearing loss. We report that concurrent administration of N-methyl-D-aspartate (NMDA) antagonists markedly attenuates both the hearing loss and destruction of cochlear hair cells in guinea pigs treated with aminoglycoside antibiotics. These findings indicate that aminoglycoside-induced hearing loss is mediated, in part, through an excitotoxic process. The high correlation (Spearman correlation coefficient 0.928; P < 0.01) obtained between the relative cochleotoxicities of a series of aminoglycosides in humans and the potencies of these compounds to produce a polyamine-like enhancement of [3H]dizocilpine binding to NMDA receptors is consistent with this hypothesis, and provides a simple in vitro assay that can predict this aspect of aminoglycoside-induced ototoxicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
N-Metilaspartato
/
Antagonistas de Aminoácidos Excitatórios
/
Perda Auditiva
/
Antibacterianos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article