Your browser doesn't support javascript.
loading
Production of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor by carcinomas in a dog and a cat with paraneoplastic leukocytosis.
Sharkey, L C; Rosol, T J; Gröne, A; Ward, H; Steinmeyer, C.
Afiliação
  • Sharkey LC; Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA.
J Vet Intern Med ; 10(6): 405-8, 1996.
Article em En | MEDLINE | ID: mdl-8947874
A dog with a pulmonary papillary carcinoma and a cat with a dermal tubular adenocarcinoma had profound paraneoplastic neutrophilic leukocytosis with no clinically detectable inflammatory foci. To investigate the mechanism of the leukocytosis, oligonucleotide primers were designed from the cDNA sequences of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) of dogs. Reverse transcription polymerase chain reaction was performed on tumor tissues, and specific amplification of G-CSF and GM-CSF was obtained with the tumor RNA in the dog. The tumor RNA in the cat demonstrated specific amplification of G-CSF but not GM-CSF. These findings are consistent with the production of G-CSF and/or GM-CSF by neoplasms as a mechanism for paraneoplastic leukocytosis in small animals.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Paraneoplásicas / Neoplasias Cutâneas / Carcinoma Papilar / Doenças do Gato / Adenoma / Fator Estimulador de Colônias de Granulócitos / Fator Estimulador de Colônias de Granulócitos e Macrófagos / Doenças do Cão / Leucocitose / Neoplasias Pulmonares Idioma: En Ano de publicação: 1996 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes Paraneoplásicas / Neoplasias Cutâneas / Carcinoma Papilar / Doenças do Gato / Adenoma / Fator Estimulador de Colônias de Granulócitos / Fator Estimulador de Colônias de Granulócitos e Macrófagos / Doenças do Cão / Leucocitose / Neoplasias Pulmonares Idioma: En Ano de publicação: 1996 Tipo de documento: Article