The inverse association between tuberculin responses and atopic disorder.
Science
; 275(5296): 77-9, 1997 Jan 03.
Article
em En
| MEDLINE
| ID: mdl-8974396
ABSTRACT
Human immune responses are heterogeneous and may involve antagonism between T helper (TH) lymphocyte subsets and their cytokines. Atopy is characterized by immediate immunoglobulin E (IgE)-mediated hypersensitivity to agents such as dust mites and pollen, and it underlies the increasingly prevalent disorder asthma. Among Japanese schoolchildren, there was a strong inverse association between delayed hypersensitivity to Mycobacterium tuberculosis and atopy. Positive tuberculin responses predicted a lower incidence of asthma, lower serum IgE levels, and cytokine profiles biased toward TH1 type. Exposure and response to M. tuberculosis may, by modification of immune profiles, inhibit atopic disorder.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculina
/
Tuberculose
/
Hipersensibilidade Tardia
/
Hipersensibilidade Imediata
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article