PDGF mediates a neuron-astrocyte interaction in the developing retina.
Neuron
; 17(6): 1117-31, 1996 Dec.
Article
em En
| MEDLINE
| ID: mdl-8982160
ABSTRACT
Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. To test this, we inhibited PDGF signaling in the eye with a neutralizing anti-PDGFR alpha antibody or a soluble extracellular fragment of PDGFR alpha. These treatments inhibited development of the astrocyte network. We also generated transgenic mice that overexpress PDGF-A in RGCs. This resulted in hyperproliferation of astrocytes, which in turn induced excessive vasculogenesis. Thus, PDGF appears to be a link in the chain of cell-cell interactions responsible for matching numbers of neurons, astrocytes, and blood vessels during retinal development.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Fator de Crescimento Derivado de Plaquetas
/
Comunicação Celular
/
Astrócitos
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article