Enteropathogenic E. coli exploitation of host epithelial cells.
Ann N Y Acad Sci
; 797: 26-31, 1996 Oct 25.
Article
em En
| MEDLINE
| ID: mdl-8993348
ABSTRACT
Enteropathogenic E. coli (EPEC) is a leading cause of neonatal diarrhea worldwide. These organisms adhere to the intestinal cell surface, causing rearrangement in the epithelial cell surface and underlying cytoskeleton, resulting in a structure termed an attaching/effacing (A/E) lesion. A/E lesion formation is thought necessary for EPEC-mediated disease. EPEC secretes several proteins that trigger signal transduction, intimate adherence, and cytoskeletal rearrangements in epithelial cells. Additionally, it produces intimin, an outer membrane product that mediates intimate adherence. Together these various bacterial molecules contribute to the intimate relationship that is formed by EPEC with host epithelial cells which results in A/E lesion formation and diarrhea.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Adesinas Bacterianas
/
Proteínas de Escherichia coli
/
Diarreia
/
Escherichia coli
/
Infecções por Escherichia coli
/
Mucosa Intestinal
Limite:
Humans
/
Newborn
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article