Antigen stimulation of human pulmonary smooth muscle: an in vitro model of inflammation.
Cell Biol Toxicol
; 12(4-6): 239-44, 1996 Dec.
Article
em En
| MEDLINE
| ID: mdl-9034615
ABSTRACT
Human airways in vitro contract when stimulated by anti-IgE, whereas human pulmonary vessels relax. Leukotriene D4 (LTD4) induced a contractile response in the airways, while in pulmonary vessels both contractions and relaxations were observed. The LTD4 contractions in airways were blocked by cysLT1 receptor antagonists (MK 571, ICI 198615, and BAY x7195). In contrast none of the compounds affected the LTD4 contractions of pulmonary veins. These results suggest that the leukotrienes which are released during antigen challenge of airways and pulmonary vessels may be acting at distinct receptors in the human lung.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Brônquios
/
Músculo Liso
/
Antígenos
Limite:
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article