Effect of strychnine on rat locus coeruleus neurones during sleep and wakefulness.
Neuroreport
; 8(1): 351-5, 1996 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-9051809
ABSTRACT
The noradrenergic neurones of the locus coeruleus (LC) discharge tonically during wakefulness, decrease their activity during slow wave sleep and are virtually quiescent during paradoxical sleep. We recently demonstrated an inhibitory glycinergic input to the locus coeruleus and proposed that this could be responsible for inhibition of the LC during paradoxical sleep. To test this proposal, we developed a method combining polygraphic recordings, iontophoresis and single-unit extracellular recordings in the unanaesthetized head-restrained rat. Iontophoretically applied strychnine, a specific glycine antagonist, induced strong excitation of LC neurones during paradoxical sleep, but also during slow wave sleep and wakefulness. These results suggest that glycine tonically inhibits noradrenergic LC neurones throughout the entire sleep-waking cycle and not only during paradoxical sleep.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Estricnina
/
Vigília
/
Locus Cerúleo
/
Glicinérgicos
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article