Characterization of allergens from deer: cross-reactivity with allergens from cow dander.
Clin Exp Allergy
; 27(2): 196-200, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9061220
ABSTRACT
BACKGROUND:
Animal hair/dander proteins frequently cause Type I hypersensitivities. Species-specific and broadly cross-reacting allergens have been characterized in the past.METHODS:
Sera from eight individuals suffering from symptoms due to exposure to deer and deer-derived products were investigated by immunoblotting. Extracts from deer, dog, cat, horse, rabbit and cow, respectively, were tested for IgE-binding. To reveal cross-reactivities patients' sera were preadsorbed with these extracts prior to testing with deer extract.RESULTS:
Deer allergens with the molecular mass of 22 and 25 kD (major allergens), as well as 60 kD were identified. The 22 and 25 kD allergens are cross-reactive with the corresponding cow allergens.CONCLUSION:
Deer allergy is a rare sensitization mainly affecting persons exposed to deer, who displayed an atopic disposition. From our results it can be assumed that this hypersensitivity is partly associated with allergy to cow dander.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bovinos
/
Cervos
/
Alérgenos
/
Cabelo
Limite:
Adult
/
Aged
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article