Hepatotoxicity after a short course of low-dose pyrazinamide.
Acta Gastroenterol Belg
; 59(4): 251-3, 1996.
Article
em En
| MEDLINE
| ID: mdl-9085628
ABSTRACT
We report on a patient who developed extensive centrolobular liver necrosis after a treatment with low-dose (25 mg/kg/d) pyrazinamide for only 4 weeks, combined with rifampicin, 600 mg/d). In the past, the patient already developed severe aminotransferase elevations under isoniazid treatment. After prompt withdrawal of the drugs, a gradual decline of the aminotransferases was observed. No signs of hepatic failure developed. Pyrazinamide has to be used with caution, even in low-dose, especially when combined with rifampicin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazinamida
/
Doença Hepática Induzida por Substâncias e Drogas
/
Antituberculosos
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article