Stimulus generalization of fear responses: effects of auditory cortex lesions in a computational model and in rats.
Cereb Cortex
; 7(2): 157-65, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-9087823
ABSTRACT
The conditioning of fear responses to a simple acoustic stimulus (pure tone) paired with footshock can be mediated by the transmission of auditory information to the lateral nucleus of the amygdala from either the auditory thalamus or the auditory cortex. We examined the processing capacity of the thalamo-amygdala pathway by making lesions of the auditory cortex and testing the extent to which conditioned fear responses generalized to tones other than the one paired with footshock. Two studies were performed, one in an anatomically constrained computational model of the fear conditioning network and the other in rats. Stimulus generalization was unaffected in both. These findings support the validity of the model as an approach to studying the neural basis of conditioned fear learning, and in addition suggest that the thalamo-amygdala pathway, possibly by the use of population coding, is capable of performing at least crude stimulus discriminations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Auditivo
/
Tálamo
/
Córtex Cerebral
/
Medo
/
Tonsila do Cerebelo
/
Modelos Neurológicos
/
Rede Nervosa
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article