Molecular cloning and characterization of a new receptor for galanin.
FEBS Lett
; 405(3): 285-90, 1997 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-9108306
ABSTRACT
Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior. Its effects are mediated through G-protein-coupled receptors (GPCR) for which only a single type has been cloned, GAL receptor 1 (GALR1). We describe the cloning of a second galanin receptor type, GALR2, from rat hypothalamus. The GALR2 amino acid sequence is 38% identical to GALR1 and is pharmacologically similar to GALR1 when expressed in COS-7 cells. GALR2 is encoded by a single gene containing at least one intron and expressed in a diverse range of tissues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores dos Hormônios Gastrointestinais
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article