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Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis.
Naeve, G S; Ramakrishnan, M; Kramer, R; Hevroni, D; Citri, Y; Theill, L E.
Afiliação
  • Naeve GS; Department of Molecular Biology, Amgen Inc., Thousand Oaks, CA 91320, USA.
Proc Natl Acad Sci U S A ; 94(6): 2648-53, 1997 Mar 18.
Article em En | MEDLINE | ID: mdl-9122250
Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression. A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity. This molecule, named neuritin, is expressed in postmitotic-differentiating neurons of the developing nervous system and neuronal structures associated with plasticity in the adult. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. These data implicate neuritin as a downstream effector of activity-induced neurite outgrowth.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Neuropeptídeos / Encéfalo / Neuritos / Fatores de Crescimento Neural / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 1997 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transcrição Gênica / Neuropeptídeos / Encéfalo / Neuritos / Fatores de Crescimento Neural / Neurônios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 1997 Tipo de documento: Article