delta 9-Tetrahydrocannabinol increases proopiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus.
Eur J Pharmacol
; 323(2-3): 193-5, 1997 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-9128838
ABSTRACT
delta 9-Tetrahydrocannabinol, the main psychoactive component of cannabis, produces a large spectrum of pharmacological effects, many of which have been linked to interaction with the opioid system. The aim of this study was to examine the effects of delta 9-tetrahydrocannabinol on proopiomelanocortin (POMC) gene expression in the arcuate nucleus of the hypothalamus and anterior lobe of the pituitary. We report, for the first time, that a 5-day treatment with delta 9-tetrahydrocannabinol (5 mg/kg per day, i.p.) increased (38%) POMC mRNA levels in the arcuate nucleus of the hypothalamus but was without effect in the anterior lobe of the pituitary. These data indicate that delta 9-tetrahydrocannabinol stimulates opioid gene expression and regulates distinctively POMC in the hypothalamus and the anterior lobe of the pituitary in the rat.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dronabinol
/
Núcleo Arqueado do Hipotálamo
/
Pró-Opiomelanocortina
/
Expressão Gênica
/
Alucinógenos
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article