Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation.
Development
; 124(9): 1643-51, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9165113
ABSTRACT
We show that retinoid receptor antagonists applied to the presumptive wing region block the formation of a zone of polarizing activity (ZPA). This suggests a direct relationship between retinoid signaling and the establishment of the ZPA. We provide evidence that the Hox gene, Hoxb-8, is a direct target of retinoid signaling since exogenously applied RA rapidly induces this gene in the absence of protein synthesis and, moreover, retinoid receptor antagonists down-regulate Hoxb-8 expression. In addition, we find that, in the lateral plate mesoderm, the domains of Hoxb-8 expression and of polarizing activity are coextensive. Taken together, these findings support the hypothesis that retinoids are required for the establishment of a ZPA, and that retinoids act, at least in part, through Hoxb-8, a gene associated with ZPA formation (Charité et al., 1994).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Tretinoína
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Glicoproteínas de Membrana
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Transdução de Sinais
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Proteínas do Ovo
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Receptores do Ácido Retinoico
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Proteínas de Homeodomínio
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Mesoderma
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article