Induction of tolerance and mossy fibre neuropeptide-Y expression in the contralateral hippocampus following a unilateral intrahippocampal kainic acid injection in the rat.
Neurosci Lett
; 227(2): 135-9, 1997 May 16.
Article
em En
| MEDLINE
| ID: mdl-9180222
ABSTRACT
We have previously reported an ectopic expression of neuropeptide-Y (NPY) immunoreactivity in mossy fibres (MFs) in the contralateral hippocampus following a unilateral intrahippocampal (IH) injection of kainic acid (KA). In the present study we report that, in addition to MF NPY expression, unilateral IH KA injections also induce tolerance towards a subsequent intracerebroventricular (ICV) contralateral KA injection, resulting in a reduction in the number of overt seizures and degree of cell loss.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeo Y
/
Tolerância a Medicamentos
/
Hipocampo
/
Ácido Caínico
/
Fibras Nervosas
Limite:
Animals
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article