Xenoantisera to allotypic specificities of HLA-A and B antigens. Serological characterization.
Transplantation
; 28(4): 333-8, 1979 Oct.
Article
em En
| MEDLINE
| ID: mdl-92080
ABSTRACT
By using the lysostrip and the blocking of cytotoxicity by Fab2 fragments, HLA-A and B antibodies were detected in sera from rabbits and goats immunized with human high-density lipoprotein (HDL)-associated HLA antigens isolated from sera and from cultured lymphoid cells. After appropriate absorptions, the xenoantisera became specific for HLA-A and B alloantigens, reacted with the same structures as alloantisera, and displayed the same patterns of cross-reactions as alloantisera; however, several xenoantisera contained antibodies cross-reactive with antigens coded by the A and B loci. Our data indicate that HDL-associated HLA antigens isolated from lymphoid cells and from serum efficiently elicit xenoantibodies to allotypic specificities of the human histocompatibility system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA
/
Soros Imunes
/
Especificidade de Anticorpos
/
Reações Antígeno-Anticorpo
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article